Read e-book online Allergens and respiratory pollutants: The role of innate PDF

By Marc A. Williams

ISBN-10: 1907568549

ISBN-13: 9781907568541

ISBN-10: 1908818069

ISBN-13: 9781908818065

Pt. 1. floor amendment concepts -- pt. 2. Analytical thoughts and purposes

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Though there are many other structural and immune cells distributed throughout the lung architecture, cells that constitute the pulmonary innate immune system including basophils, mast cells, neutrophils, natural killer (NK) cells, NKT cells, airway epithelial cells in addition to specialized DC subsets all play key roles in protective host immune responses and allergic An introduction to allergic inflammation 9 inflammation. Airway DC have been identified throughout the conducting airways, including the peribronchial and mediastinal lymph nodes, pulmonary vascular system, pleural fluid and pulmonary interstitial cells, where DC are interdigitated to rapidly respond to, sense, take up and process environmental aeroallergens, particulate agonists and microbial pathogens.

There is compelling evidence in support of the hygiene hypothesis. For example, many studies have shown that allergic inflammatory and autoimmune diseases are more frequent in the industrialized parts of the world than in less developed or Third World countries. (103–105) By contrast, epidemiological and population-based studies have shown that in those countries gaining in socio-economic wealth – and presumably adopting a An introduction to allergic inflammation 17 more Westernized adherence to greater hygiene and levels of near “clinical cleanliness” in their homes, occupational environment and so forth – the development and incidence of such allergic or autoimmune disorders increases.

Other factors other than family history contribute to allergic asthmatic risk, such as lifestyle and socio-economic factors including rural versus urban living environments, cigarette smoking habits of the asthmatic individual, prior history of viral and/or bacterial lung infections, aeroallergen or indoor allergen exposure levels, occupational allergen exposures and environmental pollution exposure levels from vehicle emissions or high ambient pollutant particles in urban or suburban districts.

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Allergens and respiratory pollutants: The role of innate immunity by Marc A. Williams

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