By J.K. Aronson (Eds.)
The negative effects of gear Annual is designed to supply a serious and up to date account of recent info regarding hostile drug reactions and interactions from the clinician's standpoint. less than the supervision of the sequence editors, a world workforce of professional authors have collected jointly the most recent info on antagonistic drug results from the overseas literature. as well as describing new stories of difficult drug results, the authors have subjected these experiences to severe research, environment them into context when it comes to scientific relevance and significance, and cross-referring to earlier reviews the place beneficial. New antagonistic results are suggested and evaluated and formerly suggested opposed results are re-evaluated within the gentle of the latest details. a unique function is the studies, within which chosen opposed results are mentioned extensive. using the publication is more desirable by way of separate indexes, permitting the reader to go into the textual content through drug identify, opposed influence identify, or drug interplay. the present Annual is the 1st replace of the normal encyclopaedic paintings during this box, http://www.elsevier.nl/locate/isbn/0444500936Meyler's unwanted effects of gear, Fourteenth version, which used to be released in December 2000.
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Extra resources for A world-wide survey of new data and trends in adverse drug reactions
Shively BK, Roldan CA, Gill EA, Najarian T, Lora SB. Prevalence and determinants of valvulopathy in patients treated with dexfenfluramine. Circulation 1999; 100: 2161-7. 40. , Gottdiener JS, Gwynne JT. Prevalence of valvular regurgitation associated with fenfluramine three to five months 10 after discontinuation of treatment. J Am Coll Cardiol 1999; 34: 2088-95. 41. Mangion JR, Habboub AA, Kamat BR, Tam SKC. Transesophageal echocardiography with pathological correlation in severe valvular disease associated with fenfluramine-phentermine.
Masello W 1II, Carpenter DA. A fatality due to intranasal abuse of methylphenidate (Ritalin| J Forensic Sci 1999; 44: 220-1. 21. Hong R, Matsuyama E, Nur K. Cardiomyopathy associated with the smoking of crystal amphetamine. J Am Med Assoc 1991; 265:11524. 22. Rajs J, Falconer B. Cardiac lesions in intravenous drug addicts. Forensic Sci Int 1979; 13: 193-209. 23. Markowitz JS, Logan BK, Diamond E Patrick KS. Detection of the novel metabolite ethylphenidate after methylphenidate overdose with alcohol coingestion.
This prospective, multicenter, randomized, doubleblind, parallel group study was conducted at 71 independent study centers, and 605 patients were randomized to placebo (n = 208), metrifonate 40 or 50 mg/day (n = 200), and metrifonate 60 or 80 mg/day (n = 197); within each treatment group the dose was determined according to body weight. The treatment lasted for 24 weeks. Metrifonate improved a wide range of symptoms across all four clinical domains of Alzheimer's disease in a dosedependent manner, and was well tolerated at both doses studied.
A world-wide survey of new data and trends in adverse drug reactions by J.K. Aronson (Eds.)